Image of the galactic center obtained from observations made with different telescopes. (Credit: Ashley Barnes/Izaskun Jiménez-Serra/Juan García de la Concepción)
In a Nutshell
- Astronomers have detected the first sugar ever observed in interstellar space, a molecule called erythrulose, inside a gas cloud near the center of the Milky Way.
- Erythrulose appears to form naturally on the surface of interstellar dust grains from simpler molecules including glycolaldehyde and ethylene glycol, and computer models suggest this pathway is plausible under the extreme conditions of deep space.
- Erythrulose may have formed in space before the solar system fully developed and could have been delivered to early Earth by asteroids and meteorites, potentially contributing to the chemistry needed for life.
For billions of years, one of the biggest mysteries in science has been deceptively simple: where did life’s chemical ingredients come from? A new discovery is pushing part of that answer deeper into the cosmos than ever before. Astronomers have detected a sugar molecule floating in a giant cloud of gas near the center of the Milky Way, the first sugar ever detected in interstellar space. And it raises a real possibility worth exploring: this sugar, called erythrulose, along with related molecules, may have formed in space before the solar system fully developed and could have contributed to the chemistry available for early life on Earth, possibly arriving aboard asteroids and meteorites (though scientists are careful to say the evidence so far only suggests this, not proves it).
Erythrulose, the detected sugar, contains four carbon atoms and belongs to the same chemical family as the sugars that form the backbone of genetic material. Sugars like this one are essential to life: they power cells, form the structural scaffolding of genetic material, and help store energy. Scientists have long wondered how sugars first appeared on a young, barren Earth, since lab experiments trying to produce them under primitive Earth conditions have repeatedly yielded insufficient amounts.
Finding erythrulose drifting through space, formed naturally without any biological help, adds important new evidence to that long-running debate.
Astronomers made the discovery, described in a paper published in Nature Astronomy, near a massive molecular cloud called G+0.693−0.027, located at the center of the Milky Way, roughly 27,000 light-years from Earth. Researchers used two powerful radio telescopes, the Yebes 40-meter and the IRAM 30-meter, both in Spain, to scan across more than 91 gigahertz of radio frequencies, in effect taking a detailed chemical fingerprint of the cloud. What they found written in that fingerprint was a solid detection of erythrulose, backed by multiple independent signals.
A Sugar Hidden in a Cosmic Chemistry Lab
Molecular clouds near the galactic center are among the most chemically rich environments known in the universe. More than 340 molecules have been identified floating in interstellar space so far, including some directly relevant to the chemistry of life. G+0.693−0.027, the specific cloud targeted in this study, has become something of a scientific goldmine, yielding numerous discoveries of large molecules in recent years. Finding an actual sugar there, though, represents a major leap forward.
Every molecule vibrates and rotates in a unique way, emitting radio waves at specific frequencies, a kind of molecular fingerprint. By matching those frequencies to lab-measured data for erythrulose, the research team identified 12 distinct sets of signals, accounting for 17 individual molecular transitions, that match the predicted signature of the sugar. Six of those signal sets were classified as predominantly unblended, meaning they had minimal contamination from overlapping signals.
Using a statistical check, the team calculated that the probability of all six appearing together by sheer chance was just 0.2%, giving them strong confidence in the identification.
Erythrulose also turns out to be surprisingly abundant in this cloud, at least eight times more common than closely related three-carbon sugars, which the team searched for but could not detect at all. That’s an unusual pattern. Typically, as molecules get larger and more intricate in interstellar space, they become rarer. That erythrulose bucks the trend points to something special about how it forms.
Built From Simpler Pieces on Dust Grains
So how does a sugar end up floating in space? According to the research team’s models, erythrulose isn’t assembled all at once. Instead, it’s built up step by step on the icy surfaces of microscopic dust grains drifting through the cloud.
Two simpler molecules, glycolaldehyde (a two-carbon compound already known to exist widely in space) and ethylene glycol (a close chemical cousin), act as the raw ingredients. When these molecules stick to the surface of a dust grain and interact, they can form highly reactive fragments that then combine to produce erythrulose through a series of chemical steps. Some of those steps are accelerated by a quantum mechanical phenomenon called tunneling, where particles pass through energy barriers that would otherwise block them.
Computer simulations of this process, modeling the chemistry as it builds up over millions of years inside a collapsing cloud, predicted erythrulose abundances broadly consistent with what the telescopes actually observed.
One detail the models also captured: G+0.693−0.027 is believed to be experiencing large-scale shock waves from colliding gas clouds. These shocks can knock molecules off dust grain surfaces and release them into the gas, which is likely why erythrulose is detectable by radio telescope at all.
Space Sugar and the Origins of Life on Earth
Erythrulose, with 14 atoms in its structure, is the largest non-ring-shaped molecule identified in interstellar space to date. It is also the first molecule detected in the interstellar medium that contains four oxygen atoms, a distinction the authors note within the context of known interstellar detections, and only the second known chiral molecule (one that exists in two mirror-image versions, like a left hand and a right hand) ever detected there. That chirality matters: life on Earth uses molecules with a specific “handedness,” and where that preference originated remains one of biology’s deepest unsolved questions.
Erythrulose is also of interest because it can easily convert into other sugars when dissolved in water. It can transform into threose, a sugar tied to threose nucleic acid, a hypothetical precursor to RNA that may have played a role in pre-RNA chemistry early in life’s history. Lab experiments have already shown that the building blocks of RNA can be synthesized from mixtures containing erythrulose. Meanwhile, sugars like ribose and glucose have previously been found in primitive meteorites and in samples from asteroid Bennu, hinting that the solar system has been carrying biological raw materials for eons.
Factoring in the estimated amount of organic material that may have rained down on Earth during a period of intense asteroid bombardment between roughly 4.1 and 3.9 billion years ago, the authors suggest that erythrulose could potentially have been delivered to early Earth in some quantity, though they emphasize that this estimate depends heavily on uncertain assumptions about how much of what formed in space actually survived the journey.
This discovery doesn’t prove that life on Earth came from space. What it does show is something more specific and still important: that a sugar tied to genetic chemistry can assemble itself spontaneously in one of the harshest environments imaginable, from nothing more than simple molecules, cold dust, and time. Each such finding adds another piece to the puzzle of how life’s ingredients came to exist, and invites deeper questions about just how far back that story begins.
Paper Notes
Study Limitations
Detecting erythrulose relied on matching predicted radio signals to observed data in a region of space that is chemically extremely crowded, making it difficult to rule out all possible interference from other molecules. Of the 12 sets of signals identified, six were classified as predominantly unblended, meaning six others had some degree of contamination from overlapping signals. Computer models used to simulate erythrulose formation on dust grains did not include a full gas-phase chemical network for these organic molecules, meaning chemical reactions happening in the gas after the molecules leave the grain surface were not fully accounted for. Those models also overproduced the three-carbon sugars by large factors compared to observed upper limits, suggesting that some processes (such as how efficiently molecules are ejected from dust grains by shock waves, or how quickly they are destroyed in the gas phase) are not yet fully understood. Additionally, uncertainties remain in key reaction rates, such as how efficiently UV light breaks apart molecules of different sizes.
Funding and Disclosures
This work was supported by ERC grant OPENS (GA no. 101125858), funded by the European Union. Additional support was provided by grant number PID2022-136814NB-I00 funded by the Spanish Ministry of Science, Innovation and Universities/State Agency of Research (MICIU/AEI/10.13039/501100011033) and by ERDF/EU, among several other Spanish and European funding sources acknowledged in the paper. Computational resources were provided by CENITS and Foundation Computaex through the LUSITANIA-II high-performance computing facility. Authors declared no competing interests.
Publication Details
Paper Title: Detection of a four-carbon sugar in interstellar space
Authors: Izaskun Jiménez-Serra, Juan García de la Concepción, Herma M. Cuppen, Marta Rey-Montejo, Miguel Sanz-Novo, Víctor M. Rivilla, Jesús Martín-Pintado, Andrés Megías, Carlos Briones, David San Andrés, Laura Colzi, Shaoshan Zeng, Sergio Martín, Joseph Salaris, Antonio Martínez-Henares, Álvaro López-Gallifa, Miguel Angel Requena-Torres, Belén Tercero, Pablo de Vicente, Aran Insausti, Elena R. Alonso, and Emilio J. Cocinero
Journal: Nature Astronomy
DOI: 10.1038/s41550-026-02905-7
Received: September 11, 2025 | Accepted: May 27, 2026







