
Women who began hormone therapy between ages 45-55 displayed no clear difference in dementia risk in comparison to women who started at age 60+. (© digitalskillet1 - stock.adobe.com)
ANN ARBOR, Mich. — Recent studies are reassuring middle-aged women who are approaching menopause. Many women are concerned about the potential link between migraines, menopausal symptoms such as hot flashes and night sweats, and the risk of cardiovascular diseases like heart attacks and strokes. However, researchers from the University of Michigan are offering new insights and recommendations for managing health risks.
The studies analyze data from over 1,900 women who were part of a comprehensive long-term research project called the CARDIA study. This project tracked the health of these women from their late teens or early 30s into their 50s and 60s, providing valuable information on the factors that influence health before, during, and after menopause.
The studies are published in the journal Menopause.

The findings bring good news for most of these women, suggesting that the combined presence of migraines and prolonged menopausal symptoms like hot flashes and night sweats does not necessarily elevate cardiovascular risk, except in a specific subgroup. This subgroup comprises women who have experienced both migraines and early onset persistent vasomotor symptoms. For these women, an increased risk of cardiovascular events such as stroke and heart attack has been identified, emphasizing the importance of early and proactive risk management.
“The anxiety and dread that women with migraines and menopausal symptoms feel about cardiovascular risk is real — but these findings suggest that focusing on prevention, and correcting unhealthy habits and risk factors, could help most women,” says Dr. Catherine Kim, an associate professor of internal medicine at the University of Michigan and a primary care physician, in a statement.
For the majority, though, the studies suggest that focusing on lifestyle modifications — such as improving diet, increasing physical activity, quitting smoking, and managing blood pressure, cholesterol, and weight — can significantly mitigate cardiovascular risk. These actions align with the American Heart Association’s “Essential 8” guidelines for maintaining heart health.
Interestingly, the research also highlights that young women in their 20s and 30s who suffer from migraines might face a higher likelihood of experiencing long-term menopausal symptoms as they age. This finding points to the importance of addressing these issues early on, not only to manage symptoms but also to potentially reduce future health risks.
The study further reveals that migraines, depression, smoking, racial background, and educational level are significant predictors of who might experience persistent vasomotor symptoms later in life. This insight underscores the complexity of factors influencing women’s health over their lifetime and the importance of personalized health care strategies.
“These two studies, taken together, underscore that not all women have the same experiences as they grow older, and that many can control the risk factors that might raise their chances of heart disease and stroke later in life,” notes Dr. Kim. “In other words, women can do a lot to control their destiny when it comes to both menopause symptoms and cardiovascular diseases.”

Dr. Kim advocates for the use of new migraine treatments, such as calcitonin gene-related peptide (CGRP) antagonists, despite their cost and limited insurance coverage. These treatments target specific receptors on blood vessel cells to prevent migraines, representing a significant advancement in migraine management. Additionally, she emphasizes the potential benefits of antidepressants in managing menopausal symptoms, alongside the importance of healthy sleep habits and the cautious use of hormone therapy.
The findings from these studies not only offer hope by clarifying the relationship between migraines, menopausal symptoms, and cardiovascular risk but also stress the power of preventive health measures. By focusing on manageable risk factors and adopting healthier lifestyles, women can significantly influence their long-term health outcomes, effectively taking control of their future well-being.







