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In a nutshell
- Yoga was found to be equally effective as traditional strengthening exercises for reducing knee pain from osteoarthritis over 12 weeks
- By 24 weeks, yoga participants showed better results in pain levels, physical function, quality of life, and depression scores
- People practicing yoga at home stuck with their routines better than those doing strengthening exercises (70% vs 60% adherence), suggesting yoga might be easier to maintain long-term
TASMANIA, Australia — If you’ve got creaky, painful knees from osteoarthritis, you’ve probably heard the standard advice: strengthen those leg muscles. But according to new research, downward dog might work just as well as leg lifts.
A clinical trial published in JAMA Network Open found that yoga was just as effective as traditional strengthening exercises for reducing knee pain from osteoarthritis over a 12-week period. Even more notably, by 24 weeks, participants in the yoga group reported greater improvements in pain, physical function, and mood.
Two Approaches, Similar Short-Term Results
Researchers in Tasmania randomly assigned 117 adults with moderate knee pain to two groups—one practicing yoga and the other doing strengthening exercises. Both groups followed the same schedule: two supervised group sessions and one home session per week for 12 weeks, followed by three home sessions per week for another 12 weeks.
“We hypothesized that yoga would demonstrate superior efficacy compared with strengthening exercise in alleviating joint pain and improving functional limitations and quality of life among patients with knee osteoarthritis,” the authors write.
Over the initial 12-week period, both approaches significantly reduced pain, with no statistically significant difference between them. This confirmed the researchers’ goal of showing that yoga was not inferior to strengthening exercise.
An interesting trend appeared during the home-practice phase. Participants in the yoga group stuck with their routine slightly more often—reporting 70.2% adherence compared to 60.0% in the strengthening group. This suggests yoga may be easier to sustain at home, a crucial factor for managing arthritis long-term.
Yoga Pulls Ahead in Long-Term Benefits
While short-term pain reduction was similar between groups, by week 24 the yoga group showed more substantial gains. They performed better on the WOMAC index—a standard tool for measuring arthritis symptoms—and also reported higher quality of life, fewer depression symptoms, and faster walking speeds.
The study participants reflected a typical osteoarthritis population: mostly women (72.6%) with an average age of 62.5 years. All had been diagnosed with knee osteoarthritis and reported moderate pain levels at the outset.
Adverse events were minimal across both groups. The yoga group did report a slightly higher rate of minor issues (15.5% versus 6.8%), but these were generally mild and included temporary knee pain flare-ups, which occurred in both groups.
While the study didn’t identify a single reason why yoga helped, the authors note that its effects may be due to a combination of physical movement, mindfulness, breathing techniques, and improved body awareness. These factors have been linked to stress reduction, which may influence how people experience pain.
Beyond Pills and Procedures for Knee Arthritis
As healthcare systems increasingly look for drug-free ways to manage chronic pain, these findings offer timely insights. With concerns about opioid use and the long-term risks of anti-inflammatory medications, low-risk, accessible therapies like yoga may play a growing role in arthritis care.
For people with knee osteoarthritis, the takeaway is clear: strengthening exercises aren’t the only path to relief. When designed with care, yoga can offer a comparable—and in some ways, more sustainable—alternative, with added benefits for mental wellbeing and day-to-day function.
Paper Summary
Methodology
The randomized comparative effectiveness trial of yoga and strengthening exercise for knee osteoarthritis (YOGA) study was a single-center, assessor-blinded, active-controlled trial conducted in Southern Tasmania, Australia. Researchers recruited 117 adults aged 40+ with knee osteoarthritis and moderate knee pain (visual analog scale score ≥40/100). Participants were randomly assigned 1:1 to either yoga or strengthening exercise. Both groups received identical exercise volume: two supervised sessions and one home-based session weekly for 12 weeks, followed by three home-based sessions weekly for weeks 13-24. Outcomes were assessed at baseline and at weeks 4, 8, 12, 16, 20, and 24, with the primary outcome being change in knee pain on a visual analog scale over 12 weeks, with a predefined noninferiority margin of 10mm.
Results
For the primary outcome, both groups showed clinically meaningful pain reduction over 12 weeks, with no statistically significant difference between groups (difference: -1.1mm, 95% CI: -7.8 to 5.7mm). Yoga was found to be noninferior to strengthening exercises. By the 24-week mark, the yoga group showed modestly greater improvements in several secondary outcomes, including WOMAC pain (-44.5mm), function (-139mm), and stiffness (-17.6mm) scores; quality of life; patient global assessment; and performance on the 40-m fast-paced walk test. The yoga group also showed greater improvement in depression at 12 weeks. Both interventions showed good safety profiles and adherence, though home exercise adherence from weeks 13-24 was higher in the yoga group (70.2%) than in the strengthening group (60.0%).
Limitations
The researchers noted several limitations. They randomized fewer participants than planned (117 instead of 126) due to the COVID-19 pandemic. The study was conducted in a single Australian state, potentially limiting global generalizability. The yoga program was designed specifically for arthritis patients and does not reflect the safety or effectiveness of general community-based yoga classes. Patient-reported outcomes were not blinded due to the nature of the interventions, and the follow-up period was limited to 24 weeks.
Funding and Disclosures
The study was funded by the Rebecca L. Cooper Medical Research Foundation as part of a fellowship to Dr. Benny Antony. Dr. Singh reported being employed by and a shareholder in Eli Lilly and Company. Dr. Moonaz reported being a certified yoga therapist providing continuing education to yoga therapists and teachers. Dr. Bennell reported receiving grants from the National Health and Medical Research Council and the Medical Research Futures Fund, plus personal fees from Wolters Kluwer and Future Learn.
Publication Information
The study, titled “Yoga or Strengthening Exercise for Knee Osteoarthritis: A Randomized Clinical Trial,” was published in JAMA Network Open on April 8, 2025. The authors included Bedru J. Abafita, MSc; Ambrish Singh, PhD; Dawn Aitken, PhD; and others from the Menzies Institute for Medical Research, University of Tasmania, and collaborating institutions. The trial was registered at ANZCTR.org (Identifier: ACTRN12621000066886).







