CLEVELAND —Â A major breakthrough in the war against Alzheimer’s disease may pave the way for one of the most effective treatments to date. A team of scientists say they have successfully reversed the disease in mice.
Many more trials, tests, and hours of research remain before their method can be tried on humans, but it’s an historic step in the right direction.
The researchers, based at the Cleveland Clinic Lerner Research Institute, found that by gradually reducing an enzyme in the brain called BACE1, they reversed the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, improving their cognitive function. The scientists hope that this research will eventually produce drugs aimed at this enzyme in human brains.
“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says researcher Riqiang Yan in a news release by the Rockefeller University press.
Alzheimer’s typically starts with the abnormal buildup of beta-amyloid peptides, which gather together and form amyloid plaques in the brain, restricting recall, memory, and other crucial brain functions. BACE1 helps produce beta-amyloid peptides. There are already drugs in experimental stages that target BACE1, but because the enzyme also serves many critical purposes in the brain, there are serious side effects that have cropped up in the research thus far.
By selectively breeding mice, Yan and his team generated mice that lose their BACE1 as they grow older. Mice with no BACE1 whatsoever have been shown to develop severe neurological defects, but Yan found that by slowly reducing levels through time, the mice remained perfectly healthy.
The researchers bred these mice with those that developed Alzheimer’s at 75 days old. The offspring showed signs of Alzheimer’s disease after 75 days, despite their BACE1 levels being 50% lower than normal. But, their amyloid plaques slowly disappeared until they vanished completely at ten months old.
While the researchers noticed the absence of numerous telltale signs of Alzheimer’s disease, they also found that the rodents showed greater cognitive abilities after the removal of the enzyme.
“Our study provides genetic evidence that preformed amyloid deposition can be completely reversed after sequential and increased deletion of BACE1 in the adult,” says Yan. “Our data show that BACE1 inhibitors have the potential to treat Alzheimer’s disease patients without unwanted toxicity. Future studies should develop strategies to minimize the synaptic impairments arising from significant inhibition of BACE1 to achieve maximal and optimal benefits for Alzheimer’s patients.”
The complete study was published in the Journal of Experimental Medicine.
If mice based results were related to humans, we would have cured cancer many years ago.
Who knew mice had Alzheimer’s.
There’s no money in cures but endless “treatment”, well…..
Just another thing big phama will bury somehow to protect their profits. I wonder if anyone will die this time?
So, based on your logic. “Big Pharma” wants to kill it’s paying customers who will stop paying them when they die, rather than develop a treatment that they can charge for and keep them alive so they can make more money getting their monthly payments for the drug?
OK, I got it. Glad you clarified that for all of us non-entrepreneurs. The key to success is less customers because their all dead.
How would they know a mouse had alzheimers? They wouldn’t. The grant money flows in.
Lets wait another 10 years before they try it on a patient that’s dying now. My mother would gladly be their mouse. Just
Now can you apply this cure to Pelosi, McLame, and the rest of the Rats in DC.?
Mice, not rats.
Why would anyone want them to? Talk about a waste of resources – Geezzz…
In the hopes that they awake and realize that they need to immediately retire from pubic office.
I guess; I’d just as soon let them rot in office & progressively destroy the Democrat reputation in the process. Nothing like letting them do the job for themselves.
THE DRUG REVERSES ALZHEIMERS NOT STUPIDITY!
Now if only the researchers could remember where they put their findings.
I WOULD RATHER NOT. ELIMINATING SUCH REJECTS WILL ALLOW THE OPPORTUNITY TO REPLACE THEM WITH REAL CONSERVATIVES!
The FDA needs to let this get to human testing ASAP. There is nothing to lose.
As noted below, there is already a common herbal supplement and natural compound, ashwagandha extract, shown in two studies to reverse the disease in rodents. It hasn’t been tested in humans because it can’t be patented. Actually, it is part of the MEND protocol studies in humans, which is showing some promise. But this involved a cocktail of different things and I imagine the dosage they used is probably significantly less than optimal, although I haven’t verified that.
So, is it turmeric, or ashwagandha or what next? No sugar? Some of these might help, but the assertion that any of these are a blanket cure is pretty disingenuous, and is usually just used by chiropractors to sell supplements. It’s all over the radio here.”those drugs are killing you. I suggest you come to my chiropractic practice and buy this, this and this supplement and take them 4 times a day. My supplements all have low side effects and are very gentle”.
Yeah, OK. The last one is especially fun – a medicine (no, wait, supplement) that’s really strong that has little or no side effects. Generally not too common – except on radio ads.
That said, if it’s going to be as easy as just giving someone ashwagandha (as opposed to describing effects in test tubes), then just find ten people and give it to them and show us the results. If it works as well as an antibiotic or something, it’s pretty easy to prove. But we don’t often get that proof. And if something works for 10% of people who try it, we don’t often get honesty. Instead, we get testimonials and omission of facts.
What are you talking about. I have no interest in advertisements and have little interest in anecdotal reports. What I’m talking about are published studies showing what this compound has done in rodent models of alzheimer’s-like dementia, and no other treatments underway are showing the potential that this compound is.
Am sick and tired of reading about studies that show a cure for cancer, an end to diabetes, a solution to alzheimer’s, etc., etc. Why not test on volunteers who have terminal illnesses and save some lives more quickly…I would be first in line to help my fellow man if I were in that situation.
These researchers just want more grant money. It’s a chase for grant money. They are doing good research, but pharmaceutical and insurance companies won’t allow these potentially life saving drugs and techniques to hit the market. These companies make money off of sick people. Start curing sick people and there go the profits.
Actually it’s the FDA that heavily regulates the bringing of drugs to market, ever since the thalidomide tragedy.
…and thankfully, President Trump and his administration are doing away with much of that bureaucratic bullscheiĂŸe. New, potentially live saving drugs are going to be available years ahead of time now.
The FDA is an unconstitutional agency. There is nothing barring states from having their own equivalent, however.
There’s actually laws against that without years of animal tests. Trump wants to change that.
Trump’s already changing that. đŸ˜‰
The reason is that, first, physicians must do no harm.
Once they have enough confidence that the theory will work in humans, clinical trials will be next.
HAVE YOU EVER BEEN IN A DRUG STUDY? THEY DO CAUSE HARM. I KNOW I WAS IN ONE FOR A DRUG THAT ON 50 MILLIGRAMS EFFECTIVELY TREATED THE DISEASE WITH ZERO SIDEAFFECTS. THEY CONTINUED UPPING THE DOSE AND AS THEY DID SO I TURNED INTO A LAZY, HOMICIDAL GUMP @ 300MG 3X A DAY AND THEN A TOTALLY INACTIVE, SUICIDAL GUMP @ 400MGS 3X A DAY. I CONTACTED THE COMPANY MAKING THE DRUG WHEN THE DR SAID THAT I WAS NUTS, WHEN I DEMANDED TO HAVE THE DOSAGE LOWERED TO 50 MGS 2X A DAY. HE GOT A ROYAL ASS CHEWING FROM THE COMPANY AND THEY SENT ME TO A DIFFERENT DR, AND I WAS REDUCED TO 50 MGS 2X A DAY. I HAD NO ISSUES OR SIDEAFFECTS AT THAT DOSAGE. LESS THAN A YEAR AFTER THE DRUG WENT ONTO THE MARKET, IT WAS PULLED FOR TURNING RETINAS GOLD . POTIGA WAS THE NAME BRAND OF THE DRUG. EZOGABINE WAS THE GENERIC NAME OF THE DRUG. DR. ROSENFELD FORMERLY OF ST. LUKES HOSPITAL IN CHESTERFIELD, MO WAS THE ONE THAT RAN THE STUDY AND ACTED VERY UNPROFESSIONALLY! HE’S ABOUT TO RETIRE, BECAUSE HIS WIFE CAME DOWN WITH PARKENSINS DISEASE. DR. ROSENFELD ALSO TESTED ON PEOPLE WHO WERE INCAPABLE OF COMMUNICATION, IN ANY WAY, SHAPE, OR FORM!
Come on John, you got the placebo.
You need to turn off “ALL CAP’s”. That key on the left side of your keyboard will help you out.
That ancient relic of a motto was done away with a decade ago.
Amen brother. I’ve commented on that very thing repeatedly. Someone needs to do something about this. Researchers are milking the system while people are dying waiting for their knowledge to produce fruitful results.
The interesting thing is how many people are aware of this, and yet still can’t wrap their head around how/why researchers are doing the same thing with Global Warmingâ„¢. All one need do is use their brain a little bit; Perhaps they all have Alzheimer’s?
You saw the part about the profound side-effects? Your approach would benefit malpractice lawyers much more than patients.
Pretty much all prescription drugs have profound side effects. Print them up on the packaging and let the patient, or caregiver, decide. If you have a horrible disease that takes away who you are long before it actually kills you, you might choose to risk it.
THEY CAN. PROBLEM IS ONCE NEWS LEAKS OF THE CURE, THEN THE CREATORS USUALLY DIE A SUDDEN DEATH. THE MONEY IS IN THE MEDICENE, NOT IN THE CURE! SOME CANCER DR’S LAST YEAR WERE KILLED THAT FOUND THE CURE FOR CANCER.
Can you provide any links that support what you’re saying? Regarding people who develop a vaccine or cure that are suspiciously dead a short time later?
LAST MONTH SEVERAL SUCH STORIES RAN AND THEY WERE EITHER ON DRUDGE, CNS NEWS, OR GATESTONE INSTITUTE. CHECK THEM OUT. THE STORY WAS VERY DETAILED AND SHOWED WHERE, WHEN AND HOW THEY WERE KILLED.
The easiest way would be to quit giving people these diseases on purpose. Elite, I’m looking at YOU, scum.
Just before the drug can go public, large pharmaceutical’s buy out the manufacturer and close it down. This way, they preserve the existing stream of cash for medicines that only treat symptoms. If a new medicine can cure the disease, that puts a stop to the money coming in!
I don’t think you have a good grasp of reality here. You could patent the process/drug and basically charge whatever you want. I’m sure there are missing details here (like profound side effects, etc), but including those details generally doesn’t make for as good of a news article as only posting half of the story.
You have a logical hole in your argument, and that is that the drug companies still compete with each other. One not winning the race for alzheimer’s drugs would love to stick it to their competitors with something like this. They get money, publicity and the ability to recruit away competitors’ employees.
You guys will probably want to shoot me for saying this, but scientist have found that so-called positive ions such as what comes from cell phones and towers, smart meters, wi-fi and all the rest, slow down and sometimes stop the cilia in our brains and elsewhere.
When the cilia slow down or stop, amyloid plaque shows up. Sound familiar?
Between 1998 and 2013, aged adjusted deaths from Alzheimer’s increased 55% in the US. Seems to fit with when cell phones and towers became highly popular, used by more people and for longer periods of time.
My memory has improved since I started using a Whirling Bliss Machine for a few minutes a day. It generates negative ions which speed up the motion of the cilia.
another knock-out sub-species study… don’t get your hopes up.
So the treatment for humans will help them remember where the cheese is located?
Alzheimer’s in rodents has already been reversed in studies with Ashwagandha extract (withania somnifera). It not only stopped the disease, but reversed the brain damage. It upregulates an enzyme produced in the liver that dissolves the plaques. It also reconstructs damaged neuronal networks. See Pubmed ID’s: 22308347 and 15711595.
Alzheimer’s is simply diabetes of the brain…….do a water fast you’ll be fine
TMI
That’s good to know! Cell towers and phones also have a direct impact on the brain, producing amyloid plaque. I thought I wasn’t affected by cell towers because I don’t use a cell phone. Well all I can say is that since using a Whirling Bliss Machine that generates the right kind of ions, my memory has improved. I’ve shed a good amount of weight as well.
Whose kitchen table would I be sitting at? Someone else’s? The website isn’t even properly set up yet, yet hundreds of them are being used because of the spectacular coincidences that are occurring. I wasn’t wealthy before making this earth shattering invention, so yeah, that’s where I’m starting. No silver spoon here. But a golden invention. My invention. And yes you are deplorable – not Trumpian at all.
>spectacular coincidences<
How about proof instead of coincidences. Things that *are* can generally be proven fairly easily.
Proof of one or more coincidences? Sounds good! Since you’re the one interested in that information, it’ll be your job to finance the study.
Some people like to research a car for months before buying. Others test drive the car they like and drive it home that night. Since we don’t have the kind of information you’re looking for, you’ll be limited to the options you already have.
That’s not a problem on this end.
What else can we call them when the person is reporting their own experiences that occur while using their Whirling Bliss Machine? They didn’t do a controlled study. They used the Machine and some things happened during the course of using it. We could call them testimonials or anecdotal accounts I suppose, but we prefer to call them Hall of Fame Coincidences.
It’s not the company’s place to do self serving studies. Paying someone to conduct the studies really isn’t any different than doing it ourselves.
Obviously sent from your smartphone, while driving of course. He’s right about the cellphones, whether or not the machine works. If people can’t break their addictions soon they will be slobbering on their shirt uncontrollably in 20 years time.
REALLY? I’LL SEE I CAN ORDER SOME FOR MY MOM!
The “Now” brand is a good standardized extract and easy to find. A person could start out at one capsule twice daily with meals. Maybe work up to two capsules twice daily with meals to make sure it’s at a therapeutic level. Give it a good six months and see what happens.
Lets see if anyone remembers this story.(no pun intended)..pharma will hide it quickly
“Revolutionary Treatment? Scientists Successfully Reverse Alzheimer’s Disease In Mice”
Because the Mice are smarter than the scientists !
If scientists could reverse the dementia in liberals, that would be front page news.
they probably wouldn’t want it reversed, they seem to be happily demented….
Sounds promising. Pray that it continues to show progress
It’s a good day to be a mouse.
Hmmm…and this didn’t require stem cells from aborted fetuses?!
but…but…but…
Don’t worry, they will find a way to use them so they can continue to justify more killings
nothing worse than forgetful mice
Really, what does a mouse have to remember?
they cannot see, so all travel is done through memory of the maze, or your attic
I thought maybe the kept losing their keys and couldn’t remember their grand mice’s names
Where the cheese is.
How to tell the boys from the girls?
Oh I forgot that’s the human problem.
I think mice have that part figured out. They may be more advanced than most liberals