
(Credit: © Robert Kneschke - stock.adobe.com)
In a Nutshell
- People who picked their own therapy (tai chi or mindfulness) did just as well as people who were randomly assigned one, meaning personal choice didn’t boost or hurt the results.
- Both mindfulness meditation and tai chi/qigong programs led to meaningful improvements in fatigue and pain interference compared with a waitlist group that received no program yet.
- Tai chi also improved sleep quality, while mindfulness’s effect on sleep did not reach statistical significance.
A study of 587 cancer survivors found that both tai chi and mindfulness meditation eased fatigue and reduced how much pain interfered with daily life, whether people chose their own program or were randomly assigned one. Tai chi also clearly improved sleep quality, which meditation didn’t match.
Published in the Journal of Clinical Oncology, the study followed people who had finished cancer treatment but were still struggling with significant emotional distress. Some chose between a nine-week mindfulness program or an eleven-week tai chi and qigong program based on personal preference. Others agreed to be randomly placed into one or the other, letting scientists test something rarely studied: whether getting a first-choice program actually makes a treatment work better.
It turns out it doesn’t. People who picked their own practice improved about as much as those who were randomly assigned one. That’s useful news for cancer centers, suggesting survivors may be able to pick whichever program appeals to them without sacrificing the benefits seen in this study.
How Researchers Tested Tai Chi and Meditation for Cancer Recovery
Researchers recruited people from cancer centers in Canada between 2016 and 2020. Participants were, on average, about 61 years old, and three out of four were women. They had been diagnosed with a range of cancers, most commonly breast cancer, followed by prostate, digestive-system, reproductive, lung, and skin cancers, among others. About half had early-stage disease. To qualify, people had to have finished their main treatment at least four months earlier and still be dealing with noticeable emotional distress, a detail the research team called unusual since most mind-body studies don’t specifically recruit people who are struggling.
Participants who had a preference chose between a nine-week mindfulness program built around meditation, gentle yoga, and group discussion, or an eleven-week tai chi and qigong program built around slow movement, breathing, and focused attention. Both required a similar time commitment. People who opted for random assignment were placed into one of the two. Everyone was then split again: some started their program right away, while others were placed on a waiting list, letting researchers compare genuine improvement with what might have happened naturally over time.
Researchers measured sleep quality, fatigue, and pain using standard surveys before the programs began and again about three months later. Pain was broken into two separate measures: how intense it felt, and how much it got in the way of daily life.
What the Study Found About Sleep, Fatigue, and Pain
Compared with people on the waiting list, those in the tai chi group saw a solid improvement in sleep quality. Mindfulness participants also slept somewhat better, but that improvement wasn’t strong enough for researchers to call it a true effect once other factors were factored in.
Fatigue told a more unified story. Both the mindfulness group and the tai chi group improved compared with the waiting list, with gains large enough that doctors would consider them meaningful for a patient’s day-to-day life. In plain terms, people in both programs felt noticeably less worn down.
Pain followed an interesting pattern. Neither program reduced how intense participants’ pain felt day to day. But both reduced how much that pain got in the way of daily life, work, mood, and relationships. Study authors connected this to the pedagogy of mind-body training, which teaches people that discomfort itself may not disappear even as the extra layer of resistance and worry eases. The trial wasn’t designed to prove why pain interference improved, but seeing it drop while pain intensity held about steady fits that idea.
One finding had nothing to do with which practice people did, and everything to do with how they ended up in it. What mattered was simply starting a program right away instead of sitting on a waiting list. Getting started beat waiting around, while a preferred option offered no extra lift over a randomly assigned one.
Researchers also examined whether improvements in sleep, fatigue, and pain were connected rather than happening on their own. They were. People who slept better tended to also report less fatigue and less pain interference, even after accounting for age, sex, and cancer stage. Those connections were modest but consistent enough to suggest the three symptoms move together rather than independently.
Why Cancer Survivors Might Not Need to Overthink Tai Chi vs. Meditation
For someone newly finished with cancer treatment and drowning in decision fatigue, this study offers something rare: permission to just pick. There’s no evidence here that agonizing over which mind-body program is “better” pays off, since both delivered real relief for fatigue and pain interference, while tai chi also showed a statistically significant sleep improvement over the waitlist. Notably, the two practices didn’t differ significantly on any measure. The takeaway isn’t that one beats the other across the board. It’s that showing up to either one beats staying on a waiting list, and survivors can trust their own gut preference without worrying they’re missing out by not being randomly assigned. Given that improvements in sleep, fatigue, and pain tended to move together, treating them as a connected cluster rather than entirely separate problems may be worth exploring in how cancer recovery care gets designed going forward.
Paper Notes
Limitations
Study authors noted that missing data and participant dropout, discussed in earlier publications about this trial, may have reduced the precision of the results. Because researchers combined data from people who chose their program with data from those randomly assigned in order to increase statistical power, this pooling could mask differences between the two approaches and should be interpreted cautiously. Their analysis also tested many outcomes, time points, and models, which increases the chance that some borderline results reflect chance rather than a true effect. The authors emphasized that these were secondary, exploratory findings and should be read alongside the trial’s primary outcomes, with attention to the overall pattern of results rather than any single number. Participants also started with relatively mild sleep problems at baseline, so they may not have had as much room to improve as people selected specifically for severe insomnia in other studies.
Funding and Disclosures
Funding came from a grant from the Lotte & John Hecht Memorial Foundation to Dr. Linda E. Carlson. Dr. Carlson reported royalties from books published through the American Psychological Association and New Harbinger Books, and an uncompensated relationship with Mobio Interactive. Dr. Daniel Santa Mina reported employment with Shoppers Drug Mart, ownership interest in PrehabRx, honoraria from AstraZeneca, Fresenius Kabi, Merck, and Novartis, and travel support from Novartis. Dr. Peter M. Wayne reported another relationship with the Tree of Life Tai Chi Center. The study’s authors reported no other conflicts of interest.
Publication Details
Paper Title: “Mindfulness and Tai Chi for Sleep, Fatigue, and Pain in Distressed People After Cancer Treatment: A Partially Randomized Patient-Preference Comparative Effectiveness Trial”
Authors: Yan Ma, Linda E. Carlson, Jennifer M. Jones, Oluwaseyi A. Lawal, Devesh Oberoi, Katherine-Ann Piedalue, Daniel Santa Mina, Michael Speca, and Peter M. Wayne
Journal: Journal of Clinical Oncology
DOI: 10.1200/JCO-25-01967







