(© LIGHTFIELD STUDIOS - stock.adobe.com)
In A Nutshell
- Women aged 63-99 with the strongest grip had a 33% lower risk of death over eight years compared to those with the weakest grip
- The survival benefits held even for women who didn’t meet recommended weekly exercise levels
- Grip strength predicted longevity independent of how much women moved each day, as measured by wearable devices
- A simple 60-second grip strength test could become as routine as checking blood pressure to catch early decline
Forget the treadmill for a moment. A study of nearly 5,500 older women found that muscular strength may be one of the best predictors of longevity. Researchers tracking women aged 63 to 99 for over eight years discovered that those in the highest grip-strength group had about a 33% lower risk of death compared to those in the lowest group. Surprisingly, the benefits held up even in women who did not meet recommended weekly activity levels.
Many health guidelines emphasize aerobic exercise like walking, jogging, or cycling. Strength training often gets mentioned as an afterthought. But this research, published in JAMA Network Open, tells a different story. Among the women studied, muscular strength was linked to a lower risk of death regardless of how much they exercised each day.
Scientists have long known that staying active helps people live longer, but most prior studies relied on people self-reporting their exercise habits. Gym memberships get exaggerated. Couch time gets minimized. This study used accelerometers (small devices worn on the hip that track every movement) to get an objective picture of who moved and who didn’t. That precision made the strength findings harder to dismiss.
Testing Strength in a Living Room
Researchers visited nearly 5,500 women at home between 2012 and 2014. Each woman squeezed a handheld device called a dynamometer as hard as she could, twice. The highest reading measured her grip strength in kilograms. They also timed how fast each woman could stand up and sit down five times without using her arms.
Then came the accelerometers. Each woman wore one for seven straight days, creating a detailed log of her daily movement patterns. Researchers followed up for the next eight years, tracking who died through medical records and national databases. By early 2023, they had documented nearly 2,000 deaths.
What Grip Strength Revealed About Longevity
Women with the strongest grip had about a 33% lower risk of death compared to those with the weakest grip, even after accounting for age, smoking, chronic diseases, body weight, and overall health. When researchers factored in how much each woman actually moved throughout the day (captured by those accelerometers), the connection weakened slightly but remained strong. Grip strength predicted survival independent of exercise habits.
The researchers also looked at walking speed, which serves as a rough measure of cardiovascular fitness. Even after accounting for that, grip strength still mattered. Upper body strength appeared to offer something distinct from heart and lung fitness.
Among women who didn’t meet the recommended 150 minutes of weekly exercise, stronger grip still meant better survival odds. The same held true for women using canes or walkers. Grip strength remained linked to lower mortality even when mobility was limited.
Why Upper Body Strength Stands Apart
Grip strength and the chair stand test measured different things. The chair test seemed to reflect overall health status and fatigue levels. While both tests were linked to mortality, grip strength showed a stronger and more consistent connection across different health conditions.
That difference matters. Upper body strength (the kind needed to open jars, carry groceries, or lift objects overhead) may become more important as people age and naturally do less walking and running. It might capture something fundamental about muscle quality that goes beyond just being able to get around.
Researchers tested whether inflammation might explain the link between strength and survival. They measured C-reactive protein, a marker of inflammation in the blood. Inflammation levels were higher in women who died, but accounting for it barely changed the strength-survival connection. Strength may influence health through multiple biological pathways.
The Bigger Picture on Muscle and Aging
Skeletal muscle does more than move the body. It stores glucose, produces proteins that regulate metabolism, and signals other organs throughout the body. Weak muscles often flag underlying problems with protein production, hormone balance, or cellular energy systems. Loss of strength also predicts hospitalizations and nursing home admissions. By preventing that cascade, maintaining strength might simply keep people independent and out of institutional care.
Current guidelines recommend muscle-strengthening activities at least two days per week. Yet strength training remains far less popular than walking, especially among older adults. Many gyms cater to younger crowds, and older women often lack access to proper instruction or equipment.
This research suggests a simple grip strength test (takes less than a minute with a handheld device) could become as routine as checking blood pressure. Catching weak grip early might prompt action before serious decline sets in. For women who can’t do regular aerobic exercise because of arthritis, heart problems, or other limitations, strength training offers an alternative route to better health. Resistance bands, light dumbbells, or bodyweight exercises can build strength without hours at the gym.
The findings held across ages, races, and body types. Whether someone was 70 or 90, normal weight or obese, Black, Hispanic, or White, the pattern remained consistent. Strength declines rapidly without resistance. Adults lose muscle mass and power at accelerating rates past 60. But muscle responds to training at any age. People in their 80s and 90s can still gain strength with appropriate exercise.
Disclaimer: This article is for informational purposes only and is not intended as medical advice. Readers should consult with qualified healthcare professionals before starting any new exercise program or making changes to their health regimen. The information presented is based on a single observational study and does not establish causation between grip strength and mortality.
Paper Notes
Study Limitations
The study measured only two aspects of strength: grip and chair stands. More elaborate tests across different muscle groups might paint a fuller picture. Researchers estimated lean body mass rather than measuring it directly through imaging. They used walking speed as a stand-in for cardiovascular fitness rather than directly measuring aerobic capacity through treadmill testing. The study didn’t systematically collect information about nutrition, which affects both muscle health and mortality risk. Because the study included only postmenopausal women enrolled in the Women’s Health Initiative, the findings may not apply to men or younger women.
Funding and Disclosures
The Women’s Health Initiative program is funded by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), U.S. Department of Health and Human Services through multiple contracts. The Objective Physical Activity and Cardiovascular Health in Older Women (OPACH) study received funding through grants R01 HL105065 and HL153462. Dr. Rebecca Seguin-Fowler reported owning StrongPeople, LLC. Dr. Charles Eaton reported receiving grants from the NIH Women’s Health Initiative during the study. Dr. Chongzhi Di reported receiving grants from the NIH during and outside the study. Dr. Andrea LaCroix reported receiving grants from the NIH and NHLBI paid to her institution during the study. The funders had no role in study design, data collection, analysis, interpretation, or manuscript preparation.
Publication Details
Authors: Michael J. LaMonte, PhD; Eric T. Hyde, PhD; Steve Nguyen, PhD; Esmeralda Castro, PhD; Rebecca A. Seguin-Fowler, PhD; Charles B. Eaton, MD; Connor R. Miller, MS; Chongzhi Di, PhD; Marcia L. Stefanick, PhD; Andrea Z. LaCroix, PhD | Journal: JAMA Network Open | Title: Muscular Strength and Mortality in Women Aged 63 to 99 Years | Publication Date: February 13, 2026 | DOI: 10.1001/jamanetworkopen.2025.59367 | Affiliations: Department of Epidemiology and Environmental Health, State University of New York at Buffalo; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; Herbert Wertheim School of Public Health and Human Longevity, University of California, San Diego; Institute for Advancing Health Through Agriculture, Texas A&M University; Departments of Family Medicine and Epidemiology, Brown University; Division of Public Health Sciences, Fred Hutch Cancer Center, Seattle; Department of Medicine, Stanford University







