Attention Deficit Hyperactivity Disorder (ADHD) medicine

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ADHD Medication Linked to 25% Lower Death Risk

In A Nutshell

  • ADHD was tied to a 71% higher risk of dying from any cause across 19 studies.
  • Suicide risk nearly doubled; injury and natural-cause deaths rose 55% and 27%.
  • Medication was linked to 25% lower death risk, based on just three studies.
  • These are averages, not forecasts for any one person.

People with ADHD face a 71% higher risk of dying from any cause than people without the condition, according to an analysis of 19 studies that together included more than 15.9 million participants across seven countries. The same research found specific increases in risk for suicide, accidental or intentional injury, and death from natural causes like disease.

A more hopeful result came from people already diagnosed with ADHD. Those who took medication for the condition had about a 25% lower risk of dying from any cause than those who did not.

Published in JAMA Network Open, the review comes from a team of British researchers who say that, to their knowledge, no earlier review had focused on ADHD alone, since the only previous one covered autism and ADHD together. ADHD, marked by persistent trouble with attention, hyperactivity, or impulsivity, was once thought to mostly affect children. Researchers now see it as often continuing into older adulthood, and the authors call it a “long-term public health concern.” Some earlier work has pointed to a six- to seven-year gap in life expectancy between people with ADHD and those without.

Analysis of 19 Studies Finds Higher ADHD Death Risk

This was not a new experiment. Instead, the researchers did a meta-analysis, a kind of study of studies that gathers earlier research and combines the numbers for a clearer overall picture, much like averaging many polls instead of trusting a single one. They searched six major research databases through July 2025, found more than 20,000 records, and narrowed them to 19 studies that tracked death rates in people with ADHD.

Those studies, published between 2012 and 2025, came from the United States, Canada, Sweden, Taiwan, the United Kingdom, Finland, and Denmark. They ranged from a Helsinki project that followed 839 people born at a single maternity unit in the early 1970s to a Danish study covering nearly 3 million. Women made up about 36% of all participants, an imbalance the authors note could simply reflect current ADHD prevalence, though females are also thought to be underdiagnosed. Most studies identified ADHD through official diagnostic records, while a few relied on self-reports or scores estimating genetic risk for ADHD.

ADHD Mortality Risk Infographic
ADHD was tied to a 71% higher risk of dying in a massive review, while medication use was linked to a 25% lower risk. (Image by StudyFinds)

Suicide Shows the Steepest Rise in ADHD Death Risk

Compared with people without ADHD, those with the condition were nearly twice as likely to die by suicide, about 55% more likely to die from injuries, whether accidental or intentional, and 27% more likely to die from natural causes. Those comparisons rested on three to five studies each, while nine studies tracked deaths from any cause, which produced the 71% figure.

A 71% higher risk is a relative comparison, not a 71-in-100 chance of dying for anyone with ADHD. In rough terms, for every 100 deaths among people without ADHD over a given stretch of time, about 171 would be expected in a similarly sized, otherwise comparable group with ADHD.

Every study in these comparisons pointed toward higher risk, but the size of the increase varied widely, and a few individual studies were less conclusive, since their results could not rule out zero added risk. Natural-cause deaths showed the steadiest numbers, while suicide and injury estimates swung far more. Even so, the combined results still showed a real link between ADHD and death risk.

No single cause explains the higher risk, according to the researchers. Depression, anxiety, and other mental health conditions are more common alongside ADHD, and stigma and social exclusion may add to the risk of suicide. Impulsivity and trouble sustaining attention may raise the odds of fatal injuries, and earlier research has linked ADHD to serious transport accidents. Natural-cause deaths may reflect heart disease and other chronic health problems, smoking, poor diet, sleep trouble, and difficulty sticking with treatment plans. Financial hardship and lower education levels may add further risk.

ADHD Medication Tied to 25% Lower Death Risk in Three Studies

Medication findings rest on the thinnest evidence of all. Only three studies, from Taiwan, Canada, and Sweden, compared death rates between people with ADHD who took medication and those who did not. People who get treatment may differ from those who do not in ways that are hard to measure, including access to health care, symptom severity, financial circumstances, and how reliably medication is taken. The analysis cannot show that the drugs themselves lower the risk of death.

Earlier research has tied ADHD medication to fewer injuries, less suicidal behavior, and less substance misuse, which could plausibly add up to fewer deaths, though some evidence links the drugs to heart-related downsides. In England, the number of people receiving ADHD medicines more than doubled over six years, to roughly 278,000 in 2023 to 2024.

That 71% figure is an average across different countries and health systems, not a forecast for any one person. Still, a condition once viewed mainly as a childhood problem carries a higher risk of death from several causes, and the authors’ push to keep diagnosis and treatment within reach through adulthood looks well founded.


Disclaimer: This article summarizes published research for informational purposes only and is not medical advice. Anyone with questions about ADHD, medication, or health risks should speak with a qualified health care professional. In the US, people in crisis can call or text 988 to reach the 988 Suicide & Crisis Lifeline.


Paper Notes

Limitations

Results varied sharply from study to study, especially for overall death risk, which the authors tie to differences in diagnostic criteria, health care systems, and social attitudes toward ADHD across countries. Many studies were dominated by male participants, which may hide risks specific to females, though the authors note that the imbalance could also reflect current ADHD prevalence. Smaller studies produce less precise estimates than large national-database studies, and studies differed in which factors, such as socioeconomic status, they accounted for. The medication analysis rested on only three studies and may be skewed by differences between treated and untreated groups, including health care access, socioeconomic status, illness severity, treatment adherence, and other psychiatric conditions, so it should not be read as proof that medication lowers death risk. One author screened all titles and abstracts, with a second author independently screening 10%, and a single reviewer rated study quality. Too few studies were available for reliable subgroup analyses, and tests for publication bias should be treated with caution for the same reason. The 15.9 million participant total adds together each study’s sample size, and several studies drew on the same national databases, so some individuals may be counted more than once. The authors call for future research on how being female, belonging to a minority racial or ethnic group, and experiencing childhood maltreatment shape death risk in people with ADHD.

Funding and Disclosures

Funding came from grant MRF-RGM-MH-24-11 from the Medical Research Foundation, awarded to coauthor Amber John, PhD. The funder had no role in the design or conduct of the study, in collecting, managing, analyzing, or interpreting the data, in preparing, reviewing, or approving the manuscript, or in the decision to submit it for publication. Coauthor Elizabeth O’Nions, PhD, reported receiving personal fees from the National Autistic Society outside the submitted work, and Dr. John reported receiving grants from the National Institute for Health and Care Research outside the submitted work. No other disclosures were reported.

Publication Details

Paper title: “Mortality Among People With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.” Authors: Lucy Corrigan, BSc; Lauren Heywood, MSc; Gavin R. Stewart, PhD; Elizabeth O’Nions, PhD; Henry Shelford, MSc; Joshua Stott, PhD; and Amber John, PhD. Corrigan, the corresponding author, and Heywood are affiliated with the Department of Psychology at the University of Liverpool, as is John, who also holds a University College London affiliation along with O’Nions and Stott. Stewart is affiliated with King’s College London, O’Nions also with the Bradford Institute for Health Research, and Shelford with ADHD UK. Journal: JAMA Network Open, 2026;9(10):e2639448. Published October 19, 2026 (accepted August 24, 2026). DOI: 10.1001/jamanetworkopen.2026.39448. The article is open access under the CC-BY license.

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