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A Stricter Obesity Definition Would Flag Far More Adults, Data Suggest

In A Nutshell

  • A national study estimates that about 26 percent of U.S. adults with a “normal” BMI already meet criteria for clinical obesity, a diagnosis that requires both excess body fat and signs of organ or physical harm.
  • Clinical obesity rose with weight, from roughly 26 percent at normal BMI to more than 50 percent in the overweight range and about 85 percent in the most severe obesity category.
  • Measuring excess fat with two or three waist-based measurements flagged about 78 percent of adults, close to double the share caught by BMI alone.
  • Because the data captured a single point in time, it cannot prove the fat caused the health problems, and the clinical obesity definition itself is new and not yet validated.

Stepping on a bathroom scale feels like an honest verdict. A new national study says that verdict can miss a health problem that is already underway. Roughly one in four American adults whose weight reads as “normal” on the standard charts already carry the kind of organ or physical trouble that defines a newer, stricter diagnosis called clinical obesity.

That diagnosis does not rest on weight alone. It pairs two things: extra body fat, measured around the waist and hips rather than by weight on a scale, and real evidence of organ or physical trouble of the kind excess fat is linked to, such as high blood pressure, troubled blood sugar or cholesterol, a fat-laden liver, or difficulty with everyday movement. A person can clear the weight bar and still meet both halves of that definition.

Researchers at the University of Colorado, the University of Southern California, and New York University ran the numbers on a large, nationally representative sample and found the gap is wide. Among adults in the “overweight” range, more than half qualified for clinical obesity. Among those in the most severe weight category, the figure climbed past 85 percent. In the authors’ words, clinical obesity “remains high even among persons with ostensibly normal BMI values.”

Clinical Obesity Hiding Behind a Normal Weight

For decades, body mass index has been the gatekeeper. BMI is a simple height-and-weight ratio, and a value of 30 or higher (27.5 for adults of Asian descent) has marked the line for obesity. It is cheap, fast, and printed on every clinic chart. It also cannot tell a doctor whether the extra weight is actually harming the body, which is the gap this study set out to fill.

Clinical obesity, a definition introduced by a Lancet Diabetes & Endocrinology Commission, tries to close that gap. It asks two questions instead of one. First, does the person carry excess fat, judged by waist size and related measurements? Second, is there sign of damage, a heart, liver, kidney, metabolic, or mobility problem of the sort excess fat can drive? Only a “yes” to both counts as clinical obesity. Excess fat with organs still working normally gets a different label, preclinical obesity.

That split matters because the two groups are far from equal in size. In this sample, about 24 percent of adults fell into preclinical obesity, while nearly 54 percent met the criteria for clinical obesity once researchers accounted for age, sex, and race. Plenty of people, in other words, are not just carrying extra fat; they already show a health consequence tied to it.

Five of the six cancers on the rise among both older and younger adults are linked to obesity.
A study finds about 26% of adults with a normal BMI already meet criteria for clinical obesity, a diagnosis built on body fat and organ harm. (Credit: Halfpoint on Shutterstock)

Counting Clinical Obesity in a National Sample

To get numbers that reflect the whole country, the team drew on NHANES, the National Health and Nutrition Examination Survey, using its 2021 to 2023 cycle. NHANES is one of the few studies that brings ordinary Americans in for a real physical exam, not just a questionnaire, which let the researchers measure waistlines and lab values rather than take people’s word for them.

In total, 5,642 nonpregnant adults aged 20 and older went into the analysis. Their average age was about 49. Roughly half were women, and about 61 percent were non-Hispanic White, a mix meant to mirror the adult population as a whole. One caveat sits underneath the numbers: NHANES does not capture every health measure the Lancet definition lists, so the team leaned on the exam and lab data it did have as stand-ins. By their own account, that probably undercounts clinical obesity rather than inflating it. Each person was sorted into a BMI category, from underweight up through the three classes of obesity, and then checked against waist circumference, waist-to-hip ratio, and waist-to-height ratio, along with markers of organ trouble drawn from the exam and lab work.

What emerged was a steady climb. Clinical obesity showed up in about 26 percent of adults with a normal BMI, more than 50 percent of those classed as overweight, and 85 percent of those with the most severe obesity. The bottom line is blunt: a normal number on the scale was no guarantee that a body was metabolically in the clear.

Beyond the Bathroom Scale

A second result sharpened the point. When the researchers flagged excess fat using two or three abnormal waist-based measurements, regardless of what the scale said, about 78 percent of adults qualified as carrying too much fat. That is, in the authors’ phrasing, “nearly double the prevalence detected by BMI-based definitions.”

Waist-based measures are not exotic. A tape measure and a few seconds capture waist size and the waist-to-hip ratio, both long tied to heart and metabolic risk. The study’s argument is that those cheap measurements catch people whom BMI alone waves through, including some who look perfectly average by weight.

There is a catch worth keeping in view. Because everyone was measured at a single moment, the study can show that extra fat and organ trouble tend to travel together, but it cannot prove the fat caused any one person’s high blood pressure or shaky blood sugar. The authors are direct about this, calling for future studies to test cause and effect and to track how fat affects specific organs over time.

A Possible Shift in How Doctors Screen

Most current rules for obesity care, including who gets screened for related conditions and who qualifies for newer weight-loss drugs like the incretin medicines, lean on BMI as the trigger. If a definition built on body fat and organ function were adopted instead, the pool of people flagged for attention would grow, and it would include leaner patients who never raised a red flag before.

That is a big “if.” The clinical obesity definition is young, and the authors note the proposal “is based on expert opinion and has not been validated.” Whether screening this way actually improves people’s health, rather than simply labeling more of them as sick, is an open question the researchers say needs its own trials before anything changes in the exam room.

For now, the practical message is modest and concrete. A waistline reading and a few lab values can reveal a fat-related health problem that the scale alone keeps hidden. A weight that looks fine on paper, this national snapshot suggests, is not always the same thing as a body that is fine.


Disclaimer: This article describes a cross-sectional study, which measures people at a single point in time. It can show that excess body fat and signs of organ or physical dysfunction tend to occur together, but it cannot prove that the excess fat caused those health problems. The “clinical obesity” definition used here was created by an expert commission and, as the authors note, has not yet been validated, and limits in the underlying survey data may have led the researchers to undercount cases. Estimates can also vary with how excess fat and organ dysfunction are defined. Readers should not treat these figures as a personal diagnosis; questions about individual weight and health are best directed to a clinician.


Paper Notes

Limitations

NHANES does not collect every clinical detail the Lancet Commission’s definition calls for, so several markers of organ dysfunction could not be measured. The authors say this likely caused them to undercount clinical obesity, meaning the true figures could be higher than reported. Estimates also shift depending on exactly how excess fat and organ dysfunction are defined. Beyond the data itself, the definition rests on expert opinion and has not been validated, and the cross-sectional design captures people at one moment, so it can describe associations but cannot establish that excess fat caused any measured health problem. The researchers call for prospective studies to test causality and to weigh whether screening this way improves outcomes rather than driving overdiagnosis or overtreatment.

Funding and Disclosures

Financial support came from the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award K23AA029752 (Dr. Lee). The study funder had no role in the design, conduct, or analysis of the work, or in the decision to submit it for publication. The authors state that the content is solely their responsibility and does not necessarily represent the official views of the National Institutes of Health. Disclosure forms are available with the article online. The study protocol and data set are listed as not available, and the statistical code is available on reasonable request.

Publication Details

Hirsh Elhence (Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado), Jennifer L. Dodge (Department of Population and Public Health Sciences and Division of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, California), Stephen Fuest (Department of Medicine, University of Colorado Anschutz Medical Campus), Babak J. Orandi (Department of Surgery and Department of Medicine, New York University Langone, New York, New York), and Brian P. Lee (Division of Gastroenterology and Liver Diseases, University of Southern California; corresponding author) wrote “National Prevalence of Clinical Obesity by BMI Class: A National Cross-Sectional Study.” It appears as a brief research report in the Letters section of Annals of Internal Medicine, Volume 179, Number 8, August 2026, and was published online at Annals.org on 2 June 2026. DOI: 10.7326/ANNALS-25-05287.

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